---
title: Are 4D In-Vitro Platforms the Game-changer in Understanding Skin Aging & Product Efficiency?
description: In the ever-evolving landscape of in vitro research, the transition from 3D to 4D is bound to become a paradigm shift.
---

[ReleGO 4D Organ-on-chip platform](https://info.medelink.ca/relego_4d_organ-on-chip_platform)

# [Are 4D In-Vitro Platforms the Game-changer in Understanding Skin Aging & Product Efficiency?](https://info.medelink.ca/relego_4d_organ-on-chip_platform/are-4d-in-vitro-platforms-the-game-changer-in-understanding-skin-ageing-product-performance)

 Written by [Medelink Newsletter](https://info.medelink.ca/relego_4d_organ-on-chip_platform/author/medelink-newsletter) | May 29, 2024 4:15:21 PM

## **How does a 4D in vitro platform compare to 3D?**

 

In the ever-evolving landscape of* in vitro* research, the transition from 3D to 4D is bound to become a paradigm shift. Traditionally, 3D tissue models and testing platforms have represented the most advanced systems for safety and efficacy assessments *in vitro*. However, REVIVO BioSystems’  “4th dimension”, marked by the mimicking of the blood flow, offers a revolutionary leap in understanding product performance over time.

The dynamic nature of our 4D* in vitro* platform transcends the limitations of static 3D models, providing a more comprehensive perspective that opens up new horizons for cosmetic and pharmaceutical innovation. 

 

The summary table below highlights the strengths of 4D methodologies with respect to conventional 3D ones.

 

 

 

 

 

## Greater insights into skin aging with our unique Chronological aging model

*In vitro* skin models help us to understand the mechanisms of aging, advancing the development of innovative treatments and skin care interventions. 

While informative, traditional *in vitro* models present limitations in reproducing natural biological expressions of significant proteins and gene expressions. This can hinder their ability to provide realistic insights into skin-related phenomena. 

 

With REVIVO BioSystems’ 4D *in vitro* tissue models that leverage its dynamic organ-on-a-chip technology, these skin models closely resemble native human skin where significant proteins and genes, closer to natural levels in native tissues, are expressed. We possess a skin model capable of mimicking chronological aging independently of oxidative stress, offering a more nuanced insight into the aging process of the skin.

Our 4D skin models are ready in a 'healthy' and 'youthful' state, allowing the aging process to unfold over time. Why is this a game-changer? Following the aging process, it is easy to observe a significant reduction in epidermal thickness in the aged 4D skin model and noticeable significant changes to the expression of a youth marker and proliferation. In contrast, when skin models are reconstructed in static cell culture inserts, they already exhibit certain age-related characteristics (e.g. low expression of youth and proliferation markers). As a result, their potential to provide an appropriate and accurate model for distinct anti-aging product claims can be limited. 

 

The analogy diagram and histological analysis below give a visual representation of these differences. 

 

 

 

[View full post](https://info.medelink.ca/relego_4d_organ-on-chip_platform/are-4d-in-vitro-platforms-the-game-changer-in-understanding-skin-ageing-product-performance)

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